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Where things stand As of writing, retatrutide is investigational : it is progressing through late-stage clinical trials and is not an approved medicine

Some Sjogren's patients report that tirzepatide worsens dry mouth , a symptom they already struggle with

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References: Referenced scientific publications include: Clemmons, D

This sensation of tightness can be particularly frustrating for those who lead an active lifestyle, as it can hinder participation in sports or recreational activities

It doesnt distinguish muscle from fat, and it doesnt account for waist circumference, which is a better predictor of metabolic health in most people than BMI alone 3